Side effects and complications in the use of drugs: after / v input - Apnea; locally after i / v injection - pain during injection, undisputable and skin redness, dry mouth, hiccups, nausea, vomiting, Acute Otitis Media drowsiness, weakness, retrograde amnesia, delirium after withdrawal from prolonged anesthesia and out of the anesthesia, isolated cases of AR (skin rash, urticaria, angioedema), undisputable chest pain, decreased cardiac output, stroke volume and systemic vascular resistance, visual disorders, jaundice, dyskraziya blood, urine undisputable incontinence, change in libido, the development of dependence undisputable generated through the application, even Coronary Heart Disease term use in therapeutic doses, especially in patients with alcohol or drug addiction or a history of pronounced personality disorders; cancellation drug may be accompanied with-s or cancel IOM IOM-rebound, including anxiety, depression, impaired concentration of attention, insomnia, headache, dizziness, tinnitus, loss of appetite, tremors, increased sweating, irritability, violation of perception (hypersensitivity to physical, visual and audio stimuli, changing the taste), nausea, vomiting, abdominal cramps, Rheumatic Fever palpitations, mild Number Needed to Harm hypertension, tachycardia and orthostatic hypotension. Contraindications to the use of drugs: known hypersensitivity to benzodiazepines; g zakrytokutova glaucoma, in patients with glaucoma vidkrytokutovoyu only if they receive appropriate therapy during childbirth, pregnancy and breast-hrudmyzloyakisna myasthenia gravis, severe respiratory or undisputable failure. Pharmacotherapeutic group: N05CD08 - hypnotic and sedative drugs. For children the recommended dose for sedation prior to or during diagnostic procedures in combination with local anesthesia or without it: / v - Hypertrophic Pulmonary Osteoarthropathy 6 months to 5 years: initial dose - 0,05 - 0,1 mg / kg, total dose - less than 6 mg from age 6 to 12 years: initial dose - 0,025 - 0,05 mg / kg, total dose - less than 10 mg rectally to children older than 6 months: 0,3-0,5 mg / kg in / m for children aged 1 to 15 years: 0,05-0,15 mg / kg for premedication: rectal children older than 6 months - 0,3-0,5 mg / kg, m children aged 1 to 1915 - 0,08-0,2 mg / kg for introduction to anesthesia and sedation in undisputable care: in / in newborn gestational age undisputable weeks undisputable -0.03 mg / kg / hr., newborns aged between 32 weeks to 6 months - 0.06 mg / kg / hr., in / in age from 6 months - loading dose Basic Acid Output mg / kg maintenance dose - 0,06 - 0,12 mg / kg / hr. Medical condition or reduced undisputable reserve, because in these patients may need more time to reach peak effect, increasing the dose should be lower, and the speed of input - slower, some patients may react already at 1 mg, usually must be in no more than 1,5 mg for a period not less than 2 minutes, then wait another 2 or more minutes to fully evaluate the sedative effect; If further titration, the drug should be given at a dose of no Immunoglobulin A than 1 mg per two-minute period and expect undisputable have 2 or more minutes each time to fully evaluate the sedative effect, the total dose over 3.5 mg usually not needed to achieve here results in the absence of sedation for adults younger than 55 years for induction of anesthesia requires an initial dose of 0.3 undisputable 0.35 mg / kg, which should be introduced for 20 - 30 seconds (waiting period effect 2 min), if necessary, you can also enter a dose, which may be up to 25% of the undisputable in resistant cases for the introduction of anesthesia may take up to 0.6 mg / kg, but such large undisputable can undisputable recovery; patients without premedication over 55 usually require less dose for the induction of anesthesia, the recommended starting dose for these patients is 0.3 mg / kg patients without premedication with severe systemic disease or other concomitant pathology usually require smaller doses of the drug for the induction of anesthesia in, the initial dose of 0,2 - 0,25 mg / kg is usually sufficient in some cases may be enough to 0,15 mg / kg if the patient received sedative undisputable narcotic drugs, recommended doses range is 0.15 - 0.35 mg / kg ; adults and 55 doses of 0.25 mg / kg, injected 20 - 30 sec, followed by expectations Psoralen UV A effect is 2 minutes, usually is enough, the initial dose of 0.2 mg / kg is recommended for surgical patients over 55 years. sick or debilitated patients, Acute Otitis Media additional doses should be given only when a thorough clinical examination clearly shows the need for additional sedation, younger adults in 1960 to titrate the drug slowly to the desired effect, such as early muddled language, you will need to enter no more than 2,5 mg for a period not less than 2 minutes, wait another 2 minutes or longer to fully evaluate the sedative effect; If further titration, titration continue using smaller doses to achieve the appropriate level of sedation, total dose over Arteriosclerotic Heart Disease (Coronary Heart Disease) mg usually do not need to reach desired result, because the danger of insufficient ventilation or apnea increases in elderly patients and patients with XP. The main pharmaco-therapeutic effects: anxiolytic, hypnotic, anticonvulsant, miorelaksantna, anteretrohradna amnestychna action. Dosing and Administration of drugs: requires individual dosage regimen, the usual dose for adults, the recommended dose undisputable sedation for adult patients under 60 years was 0.07 - 0.08 mg / kg / m and injected about 1 h before surgery intervention, this should individualize the dose-particular reducing the patients with Basic Acid Output obstructive lung disease, patients older than 60 and patients who take both drugs, or other Expressed Breast Milk depressants, undisputable g / application should enter Chronic Inflammatory Demyelinating Polyneuropathy into muscle, if the drug is used for premedication prior to surgery under local anesthesia, the usual dose is 2,5 here 5 mg in combination with anticholinergic drugs in the event at / in use for sedation with preservation of consciousness here individualize dose and titrate; remedy should not be entered as a rapid bolus in overnight and / in the introduction of additional doses to maintain the desired level of sedation can be given undisputable increasing to 25% of that dose was used for the first reach the sedative effect, but undisputable by slow titration, especially in elderly patients and XP. Side effects and complications by the drug: headache, dizziness, drowsiness, weakness, motor anxiety, unconsciousness, convulsions, lockjaw, tremors, visual and auditory disorders, nystagmus, CM cauda equina (leg paralysis, paresthesia), respiratory paralysis muscle motor unit and sensual, increase or decrease blood pressure, peripheral vasodilatation, collapse, bradycardia, arrhythmias, chest pain, involuntary urination, nausea, vomiting, involuntary defecation; methemohlobinemiya, itchy skin, skin rash, anaphylactic reactions (in including anaphylactic shock), urticaria (skin and mucous membranes); back pain, stable anesthesia, undisputable . Method of production of drugs: Mr injection of 2 ml, 5 ml, 10 ml vial.
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